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Aron, A. & Zavaleta, C. Current and Developing Lymphatic Imaging Approaches for Elucidation of Functional Mechanisms and Disease Progression. Molecular Imaging and Biology. (2023).


Hsu, J.C., Tang, Z., Eremina, O.E., Sofias, A.M., Lammers, T., Lovell, J.F., Zavaleta, C., Cai, W. & Cormode, D.P. Nanomaterial-based contrast agents. Nature Reviews Methods Primers 3, 30 (2023).


Chiang, H.J., Koo, D.E.S., Kitano, M., Burkitt, S., Unruh, J.R., Zavaleta, C., Trinh, L.A., Fraser, S.E. & Cutrale, F. HyU: Hybrid Unmixing for longitudinal in vivo imaging of low signal-to-noise fluorescence. Nat Methods 20, 248-258 (2023).


Eremina, O.E., Czaja, A.T., Fernando, A., Aron, A., Eremin, D.B. & Zavaleta, C. Expanding the Multiplexing Capabilities of Raman Imaging to Reveal Highly Specific Molecular Expression and Enable Spatial Profiling. ACS Nano (2022).


Salinas, H.R., Miyasato, D.L., Eremina, O.E., Perez, R., Gonzalez, K.L., Czaja, A.T., Burkitt, S., Aron, A., Fernando, A., Ojeda, L.S., Larson, K.N., Mohamed, A.W., Campbell, J.L., Goins, B.A. & Zavaleta, C. A colorful approach towards developing new nano-based imaging contrast agents for improved cancer detection. Biomaterials science 9, 482-495 (2021).


Miyasato, D.L., Mohamed, A.W. & Zavaleta, C. A path toward the clinical translation of nano-based imaging contrast agents. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 13, e1721 (2021).


Eremina, O.E., Eremin, D.B., Czaja, A. & Zavaleta, C. Selecting Surface-Enhanced Raman Spectroscopy Flavors for Multiplexed Imaging Applications: Beyond the Experiment. The journal of physical chemistry letters 12, 5564-5570 (2021).


Burkitt, S., Mehraein, M., Stanciauskas, R.K., Campbell, J., Fraser, S. & Zavaleta, C. Label-Free Visualization and Tracking of Gold Nanoparticles in Vasculature Using Multiphoton Luminescence. Nanomaterials (Basel, Switzerland) 10(2020).


Zavaleta, C., Ho, D. & Chung, E.J. Theranostic Nanoparticles for Tracking and Monitoring Disease State. SLAS technology 23, 281-293 (2018).


Davis, R.M., Campbell, J.L., Burkitt, S., Qiu, Z., Kang, S., Mehraein, M., Miyasato, D., Salinas, H., Liu, J.T.C. & Zavaleta, C. A Raman Imaging Approach Using CD47 Antibody-Labeled SERS Nanoparticles for Identifying Breast Cancer and Its Potential to Guide Surgical Resection. Nanomaterials (Basel, Switzerland) 8(2018).


Elliott, D.S., Orly, L., Jos, L.C., Roopa, D., Cristina, L.Z. & Adam de la, Z. Machine learning-assisted hyperspectral analysis of plasmonic contrast agent microbiodistribution with single-particle sensitivity and sub-cellular resolution. in Proc.SPIE, Vol. 10080 100800L (2017).


Campbell, J.L., SoRelle, E.D., Ilovich, O., Liba, O., James, M.L., Qiu, Z., Perez, V., Chan, C.T., de la Zerda, A. & Zavaleta, C. Multimodal assessment of SERS nanoparticle biodistribution post ingestion reveals new potential for clinical translation of Raman imaging. Biomaterials 135, 42-52 (2017).


SoRelle, E.D., Liba, O., Campbell, J.L., Dalal, R., Zavaleta, C.L. & de la Zerda, A. A hyperspectral method to assay the microphysiological fates of nanomaterials in histological samples. eLife 5(2016).


Sensarn, S., Zavaleta, C.L., Segal, E., Rogalla, S., Lee, W., Gambhir, S.S., Bogyo, M. & Contag, C.H. A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer. Molecular imaging and biology 18, 820-829 (2016).


Kempen, P.J., Kircher, M.F., de la Zerda, A., Zavaleta, C.L., Jokerst, J.V., Mellinghoff, I.K., Gambhir, S.S. & Sinclair, R. A correlative optical microscopy and scanning electron microscopy approach to locating nanoparticles in brain tumors. Micron (Oxford, England : 1993) 68, 70-76 (2015).


Garai, E., Sensarn, S., Zavaleta, C.L., Loewke, N.O., Rogalla, S., Mandella, M.J., Felt, S.A., Friedland, S., Liu, J.T., Gambhir, S.S. & Contag, C.H. A real-time clinical endoscopic system for intraluminal, multiplexed imaging of surface-enhanced Raman scattering nanoparticles. PloS one 10, e0123185 (2015).


Lee, W.-S., Jokerst, J., Zavaleta, C., Sensarn, S. & Gambhir, S.S. Mo1932 Fluorescent Endoscopy With SERS Nanoparticle for Detecting Colon Polyp in Azoxymethane-Induced Colon Cancer Mice. Gastroenterology 146(2014).


James, M.L., Shen, B., Nielsen, C.H., Behera, D., Buckmaster, C.L., Mesangeau, C., Zavaleta, C., Vuppala, P.K., Jamalapuram, S., Avery, B.A., Lyons, D.M., McCurdy, C.R., Biswal, S., Gambhir, S.S. & Chin, F.T. Evaluation of σ-1 receptor radioligand 18F-FTC-146 in rats and squirrel monkeys using PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 55, 147-153 (2014).


Zavaleta, C.L., Garai, E., Liu, J.T., Sensarn, S., Mandella, M.J., Van de Sompel, D., Friedland, S., Van Dam, J., Contag, C.H. & Gambhir, S.S. A Raman-based endoscopic strategy for multiplexed molecular imaging. Proceedings of the National Academy of Sciences of the United States of America 110, E2288-2297 (2013).


Van de Sompel, D., Garai, E., Zavaleta, C. & Gambhir, S.S. A comparison of noise models in a hybrid reference spectrum and principal components analysis algorithm for Raman spectroscopy. Journal of Raman Spectroscopy 44, 841-856 (2013).


Smith, B.R., Zavaleta, C., Rosenberg, J., Tong, R., Ramunas, J., Liu, Z., Dai, H. & Gambhir, S.S. High-resolution, serial intravital microscopic imaging of nanoparticle delivery and targeting in a small animal tumor model. Nano today 8(2013).


Kempen, P.J., Thakor, A.S., Zavaleta, C., Gambhir, S.S. & Sinclair, R. A scanning transmission electron microscopy approach to analyzing large volumes of tissue to detect nanoparticles. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 19, 1290-1297 (2013).


Garai, E., Sensarn, S., Zavaleta, C.L., Van de Sompel, D., Loewke, N.O., Mandella, M.J., Gambhir, S.S. & Contag, C.H. High-sensitivity, real-time, ratiometric imaging of surface-enhanced Raman scattering nanoparticles with a clinically translatable Raman endoscope device. Journal of biomedical optics 18, 096008 (2013).


Bohndiek, S.E., Wagadarikar, A., Zavaleta, C.L., Van de Sompel, D., Garai, E., Jokerst, J.V., Yazdanfar, S. & Gambhir, S.S. A small animal Raman instrument for rapid, wide-area, spectroscopic imaging. Proceedings of the National Academy of Sciences of the United States of America 110, 12408-12413 (2013).


Van de Sompel, D., Garai, E., Zavaleta, C. & Gambhir, S.S. A hybrid least squares and principal component analysis algorithm for Raman spectroscopy. PloS one 7, e38850 (2012).


Kircher, M.F., de la Zerda, A., Jokerst, J.V., Zavaleta, C.L., Kempen, P.J., Mittra, E., Pitter, K., Huang, R., Campos, C., Habte, F., Sinclair, R., Brennan, C.W., Mellinghoff, I.K., Holland, E.C. & Gambhir, S.S. A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. Nature medicine 18, 829-834 (2012).


James, M.L., Shen, B., Zavaleta, C.L., Nielsen, C.H., Mesangeau, C., Vuppala, P.K., Chan, C., Avery, B.A., Fishback, J.A., Matsumoto, R.R., Gambhir, S.S., McCurdy, C.R. & Chin, F.T. New positron emission tomography (PET) radioligand for imaging σ-1 receptors in living subjects. Journal of medicinal chemistry 55, 8272-8282 (2012).


Zavaleta, C.L., Kircher, M.F. & Gambhir, S.S. Raman's "effect" on molecular imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 52, 1839-1844 (2011).


Zavaleta, C.L., Hartman, K.B., Miao, Z., James, M.L., Kempen, P., Thakor, A.S., Nielsen, C.H., Sinclair, R., Cheng, Z. & Gambhir, S.S. Preclinical evaluation of Raman nanoparticle biodistribution for their potential use in clinical endoscopy imaging. Small (Weinheim an der Bergstrasse, Germany) 7, 2232-2240 (2011).


Van de Sompel, D., Garai, E., Zavaleta, C. & Gambhir, S.S. A hybrid least squares and principal component analysis algorithm for Raman spectroscopy. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2011, 6971-6974 (2011).


Thakor, A.S., Paulmurugan, R., Kempen, P., Zavaleta, C., Sinclair, R., Massoud, T.F. & Gambhir, S.S. Oxidative stress mediates the effects of Raman-active gold nanoparticles in human cells. Small (Weinheim an der Bergstrasse, Germany) 7, 126-136 (2011).


Thakor, A.S., Luong, R., Paulmurugan, R., Lin, F.I., Kempen, P., Zavaleta, C., Chu, P., Massoud, T.F., Sinclair, R. & Gambhir, S.S. The fate and toxicity of Raman-active silica-gold nanoparticles in mice. Science translational medicine 3, 79ra33 (2011).


Thakor, A.S., Jokerst, J., Zavaleta, C., Massoud, T.F. & Gambhir, S.S. Gold nanoparticles: a revival in precious metal administration to patients. Nano letters 11, 4029-4036 (2011).


Jokerst, J.V., Miao, Z., Zavaleta, C., Cheng, Z. & Gambhir, S.S. Affibody-functionalized gold-silica nanoparticles for Raman molecular imaging of the epidermal growth factor receptor. Small (Weinheim an der Bergstrasse, Germany) 7, 625-633 (2011).


Zavaleta, C.L., Smith, B.R., Walton, I., Doering, W., Davis, G., Shojaei, B., Natan, M.J. & Gambhir, S.S. Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy. Proceedings of the National Academy of Sciences of the United States of America 106, 13511-13516 (2009).


Zavaleta, C.L., Goins, B.A., Bao, A., McManus, L.M., McMahan, C.A. & Phillips, W.T. Imaging of 186Re-liposome therapy in ovarian cancer xenograft model of peritoneal carcinomatosis. Journal of drug targeting 16, 626-637 (2008).


Zavaleta, C., de la Zerda, A., Liu, Z., Keren, S., Cheng, Z., Schipper, M., Chen, X., Dai, H. & Gambhir, S.S. Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes. Nano letters 8, 2800-2805 (2008).


Keren, S., Zavaleta, C., Cheng, Z., de la Zerda, A., Gheysens, O. & Gambhir, S.S. Noninvasive molecular imaging of small living subjects using Raman spectroscopy. Proceedings of the National Academy of Sciences of the United States of America 105, 5844-5849 (2008).


De la Zerda, A., Zavaleta, C., Keren, S., Vaithilingam, S., Bodapati, S., Liu, Z., Levi, J., Smith, B.R., Ma, T.J., Oralkan, O., Cheng, Z., Chen, X., Dai, H., Khuri-Yakub, B.T. & Gambhir, S.S. Carbon nanotubes as photoacoustic molecular imaging agents in living mice. Nature nanotechnology 3, 557-562 (2008).


Zavaleta, C.L., Phillips, W.T., Soundararajan, A. & Goins, B.A. Use of avidin/biotin-liposome system for enhanced peritoneal drug delivery in an ovarian cancer model. International journal of pharmaceutics 337, 316-328 (2007).


Zavaleta, C.L., Phillips, W.T., Bradley, Y.C., McManus, L.M., Jerabek, P.A. & Goins, B.A. Characterization of an intraperitoneal ovarian cancer xenograft model in nude rats using noninvasive microPET imaging. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 17, 407-417 (2007).


Bao, A., Phillips, W.T., Goins, B., Zheng, X., Sabour, S., Natarajan, M., Ross Woolley, F., Zavaleta, C. & Otto, R.A. Potential use of drug carried-liposomes for cancer therapy via direct intratumoral injection. International journal of pharmaceutics 316, 162-169 (2006).


Sterling, J., Goins, B., Grubbs, B., Amurao, M., Zavaleta, C., Soundararajan, A., Wang, Z., Phillips, W., Oyajobi, B. & Mundy, G. Functional and anatomical imaging allows for more sensitive monitoring of tumor burden and osteolysis in a mouse model of breast cancer metastasis to bone. in Journal of Bone and Mineral Research, Vol. 20 S326-S327 (2005).

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